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KMID : 0363320110320030387
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Journal of Korean Oriental Internal Medicine
2011 Volume.32 No. 3 p.387 ~ p.396
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The Effects of Supungsunki-hwan Partitioned Prescriptions on Obese Type 2 Diabetes Mouse Model Induced by High Fat, High Carbohydrate Diet
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Park Eun-Young
Ahn Se-Young
Ahn Young-Min
Um Jae-Young
Jang Hyeung-Jin
Lee Byung-Cheol
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Abstract
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Objectives: Recently a lot of research is being done for find antidiabetic medicine which has no side effects. This study aimed to investigate the antidiabetic and antiobesity effects of Supungsunki-hwan partitioned prescriptions on obese type 2 diabetes mouse.
Methods: Type 2 diabetes mellitus and obesity were induced by Surwit’s high fat, high sucrose diet for 8 weeks. Mice were divided into 3 groups of ND (normal diet, n=10) HFD (high fat and high sucrose diet, n=10) and SPP (high fat and high sucrose diet with Supungsunki-hwan partitioned prescriptions, n=10) groups. Body weights were measured every week. After 7 weeks, fasting blood sugar and oral glucose tolerance tests were conducted. After 8 weeks, blood samples of all mice were taken from their heart and analyzed biochemically. At the same time, epididymal fat pad and liver weights were measured. Histological size of white adipocyte were measured as well.
Results: Compared with a HFD group, body weight, fructosamine, epididymal fat pad weight and white adipocyte size decreased. High-density lipoprotein cholesterol levels increased in the SPP group.
Conclusions: These results suggest that SPP has antidiabetic and antiobesity effects in high fat, high sucrose diet induced obese mice.
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KEYWORD
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Supungsunki-hwan (Sufngshnqwn), Cornus officinalis, Dioscorea Batatas Decaisne, Aurantii fructus, type 2 diabetes, obesity
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